Isotopically Labeled Compounds
Medchemexpress LLC Cabozantinib-d6 | 1802168-46-2 | 98.1% | 50 MG
Cabozantinib-d6 is the deuterium labeled Cabozantinib. Cabozantinib is a potent multiple receptor tyrosine kinases (RTKs) inhibitor that inhibits VEGFR2, c-Met, Kit, Axl and Flt3 with IC50s of 0.035, 1.3, 4.6, 7 and 11.3 nM, respectively.
- Can be used as a tracer.
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
- Stable heavy isotopes have been incorporated into drug molecules for quantitation during drug development.
- Deuteration can affect the pharmacokinetic and metabolic profiles of drugs.
Medchemexpress LLC 1,1-Dioxothiolan-d8 | 51219-88-6 | 99.9% | 128.22 | 5 MG
1,1-Dioxothiolan-d8 is the deuterium labeled 1,1-Dioxothiolan. Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.
- Stable heavy isotopes for drug development process
- Potential to affect pharmacokinetic and metabolic profiles
Cayman Chemical CystathIonIn-d4 1mg
An internal standard for the quantification of cystathionine by GC- or LC-MS
Medchemexpress LLC L-Methionine-DL-sulfoximine | 15985-39-4 | 98.0% | 1 G
L-Methionine-DL-sulfoximine (MSX; MSO) is a highly specific and irreversible inhibitor of Glutamine synthetase (GS). It acts as a potent convulsant, primarily affecting astroglia metabolically and morphologically. This compound has been utilized to inhibit Gln-dependent ammonia-stimulated neuronal toxicity in vitro and significantly increases the release rate of fixed nitrogen in cyanobacteria. It is considered a promising candidate for research in biofertilizers and convulsive seizures (CS).
- Highly specific and irreversible inhibitor of glutamine synthetase.
- Potent convulsant affecting astroglia.
- Inhibits Gln-dependent ammonia-stimulated neuronal toxicity in vitro.
- Increases release rate of fixed nitrogen in cyanobacteria.
- Potential for research in biofertilizers and convulsive seizures.
Medchemexpress LLC Robenidine-d8 hydrochloride | 1173097-77-2 | 99.0% | 25 MG
Robenidine-d8 hydrochloride is the deuterium labeled version of Robenidine hydrochloride. Robenidine hydrochloride acts as an anticoccidial agent and is also effective against MRSA and VRE, with MIC50s of 8.1 and 4.7 μM, respectively.
- Can be utilized as a tracer.
- Can serve as an internal standard for quantitative analysis using techniques such as NMR, GC-MS, or LC-MS.
- Incorporated stable heavy isotopes into drug molecules for use as tracers in drug development.
- Potential to influence the pharmacokinetic and metabolic profiles of drugs through deuteration.
Medchemexpress LLC L-Isoleucine-¹⁵N,d10 | 73-32-5 | 142.23 | 5 MG
L-Isoleucine-15N,d10 is an isotopically labeled form of L-Isoleucine, an essential amino acid. This compound is enriched with both deuterium (d10) and nitrogen-15 (15N) isotopes, making it highly valuable for various research applications. It is commonly employed in studies involving protein structure and dynamics, metabolic pathways, and nuclear magnetic resonance (NMR) spectroscopy, where isotopic labeling helps in tracing and identifying specific molecules and their interactions.
- Isotopically labeled for research applications.
- Enriched with deuterium and nitrogen-15 isotopes.
- Useful for tracing metabolic pathways.
- Ideal for NMR spectroscopy studies.
- Supports research in protein structure and dynamics.
Medchemexpress LLC Acetylcholine-d4 chloride | 344298-94-8 | 99.2% | 1 MG
Acetylcholine-d4 (chloride) is the deuterium labeled Acetylcholine chloride. Acetylcholine chloride (ACh chloride), a neurotransmitter, is a potent and BBB-permeable cholinergic agonist. It modulates the activity of dopaminergic (DAergic) neurons through the stimulation of nicotinic acetylcholine receptors (nAChRs) and inhibits p53 mutant peptide aggregation in vitro. Stable heavy isotopes have been incorporated into drug molecules for quantitation during drug development, and deuteration has the potential to affect pharmacokinetic and metabolic profiles.
- Used as a tracer
- Used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
- Modulates dopaminergic neuron activity
- Inhibits p53 mutant peptide aggregation in vitro
- Deuterium labeled for potential pharmacokinetic and metabolic profile effects
Medchemexpress LLC Dipivefrin-d6 hydrochloride | 64019-93-8 | 99.7% | 1 MG
Dipivefrin-d6 hydrochloride is a deuterium-labeled version of Dipivefrin hydrochloride. It acts as an antiglaucoma proagent, converting into epinephrine in the cornea. This compound is valuable for quantitative analysis and drug development studies, where deuteration can influence pharmacokinetic and metabolic profiles.
- Used as a tracer.
- Functions as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
- Incorporates stable heavy isotopes for quantitation in drug development.
- Deuteration can influence pharmacokinetic and metabolic profiles of drugs.
Medchemexpress LLC α-Linolenic acid-13C18 | 287111-28-8 | 296.30 | 5 MG
α-Linolenic acid-13C18 is the 13C labeled α-Linolenic acid. α-Linolenic acid, isolated from seed oils, is an essential fatty acid that cannot be synthesized by humans. α-Linolenic acid can affect the process of thrombotic through the modulation of PI3K/Akt signaling. α-Linolenic acid possesses anti-arrhythmic properties and is related to cardiovascular disease and cancer.
- This compound can be used as a tracer.
- This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Medchemexpress LLC Ercalcidiol-d3 (25-hydroxy vitamin D2-d3) | 1217467-39-4 | 99.9% | 415.67 | 25 MG
Ercalcidiol-d3 is the deuterium labeled Ercalcidiol. Ercalcidiol is a metabolite of Vitamins D2. Ercalcidiol can be used as an indicator of vitamins D status.
- This compound can be used as a tracer.
- This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Medchemexpress LLC Azaperone-d4 | 1173021-72-1 | 1MG
Azaperone-d4 is a deuterium-labeled version of Azaperone, a dopamine antagonist that also exhibits antihistaminic and anticholinergic properties. This pyridinylpiperazine and butyrophenone neuroleptic agent is known for its antiemetic effects and is primarily used as a tranquilizer in veterinary medicine. Deuterium labeling incorporates stable heavy isotopes into drug molecules, serving as tracers for quantitation during drug development and potentially affecting pharmacokinetic and metabolic profiles.
- Deuterium labeled compound
- Dopamine antagonist
- Exhibits antihistaminic properties
- Exhibits anticholinergic properties
- Pyridinylpiperazine and butyrophenone neuroleptic agent
- Provides antiemetic effects
- Used as a tranquilizer in veterinary medicine
- Useful as a tracer for drug development
Medchemexpress LLC D-Glucose-d2 | 18991-62-3 | MFCD00064367 | 99.9% | 50 MG
D-Glucose-d2 is a deuterium-labeled form of D-Glucose. D-Glucose, a monosaccharide, plays a vital role in biology as an important carbohydrate. It acts as a carbohydrate sweetener, a critical component of general metabolism, and a signaling molecule related to cellular metabolic status and biotic and abiotic stress responses.
- Can be utilized as a tracer.
- Can serve as an internal standard for quantitative analysis using methods such as NMR, GC-MS, or LC-MS.
- Stable heavy isotopes, like deuterium, are incorporated into drug molecules for quantitation during drug development processes.
- Deuteration can potentially influence the pharmacokinetic and metabolic profiles of drugs.
Medchemexpress LLC Phenindione-d5 | 70711-53-4 | 99.5% | 5 MG
Phenindione-d5 is deuterium labeled Phenindione, which is an anticoagulant that functions as a Vitamin K antagonist.
- This compound can be used as a tracer.
- This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Medchemexpress LLC Nizatidine-d3 | 1246833-99-7 | 98.8% | 1 MG
Nizatidine-d3 is the deuterium labeled Nizatidine. Nizatidine is a potent and orally active histamine H2 receptor antagonist, used for the research of stomach and intestines ulcers. It decreases the secretion of gastric acid the stomach makes and prevents ulcers from coming back after they have healed in animal models.
- Potent and orally active histamine H2 receptor antagonist
- Used for research of stomach and intestines ulcers
- Decreases secretion of gastric acid
- Prevents ulcers from returning after healing
- Can be used as a tracer
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
- Targets the H2 receptor
Medchemexpress LLC Pantothenic acid-13C3,15N hemicalcium | 356786-94-2 | 99.3% | 1 MG
Pantothenic acid-13C3,15N (hemicalcium) is the 13C-labeled and 15N-labeled D-Pantothenic acid. D-Pantothenic acid is an essential trace nutrient that functions as the obligate precursor of coenzyme A (CoA). It plays key roles in myriad biological processes, including many that regulate carbohydrate, lipid, protein, and nucleic acid metabolism.
- Can be used as a tracer.
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.